Catalyzes the four-electron reduction of molecular oxygen to water. Active on beta-NADH, but not on alpha-NADH, beta-NADPH or alpha-NADPH. Under aerobic conditions, oxygen acts as the electron acceptor. Under anaerobic conditions, DCIP and MB can replace oxygen as the electron acceptor.
NADPH Oxidase. NADPH oxidase (NOX) is a transmembrane enzyme that is located in intracellular organelles and comprises several isoforms, including NOX1–5, NOX oxidase 1 and 2, NOX organizer 1, and NOX activator 1.